Hour 1

• List the cells where histamine is predominantly found.
• Describe the role of the Mast Cell.
• Explain histamine’s function and recall what causes its release.
• List the Histamine receptor types and where each are each found.
• Summarize or give examples of symptoms in over activation of histamine receptors.
• Many of our patients are on OTC Antihistamine medications.  List their effects, positive and negative.

Hour 2

• Quote what OAS stands for.
• Define OAS and describe what happens to those with this problem.
• Recognize at what age(s) OAS occurs.
• Memorize, recognize and describe 1-5 OAS examples.
• Educate your patient on how to deal with OAS.
• Describe NFkB as a system
• Describe NFkB’s role in canonical and non-canonical pathways
• Explain what IκBα is and its potential role in downregulating inflammation

Hour 3

• Discuss how specific herbs, nutrients, and Vitamin E work to manage histamine at both a macro and microscopic level.
• Be able to describe allergic inflammation
• Discover how NSAIDs are being noted to reduce CNS diseases with inflammation and may help manage allergic disorder(s). 
• Identify what particular NSAID is naturally occurring and available to us and your patients to help them manage their allergic inflammation.  Calculate its clinical dose and avoid its lethal dose.
• List various SPMs (Specialized Proresolving Mediators)
• Describe how SPMs can control IgE production and play a potential role in the treatment of Alzheimer’s Disease.
• Relate histamine’s role in IBS (Irritable Bowel), name and synthesize the type of 2 known GI receptors involved.